Curology Expands into Makeup

Ever wish your acne treatment worked with your makeup instead of against it? Curology just made that dream a reality with DayPrimeRx, a first-of-its-kind formula that combines a prescription acne treatment with a blurring, long-wear primer.

“DayPrimeRx solves one of the most vexing challenges in beauty and skincare — the fact that acne treatments don’t often layer well under makeup, forcing people to choose between cover and treat,” said Dr. Whitney Tolpinrud, MD, FAAD, board-certified dermatologist and Medical Director at Curology. “DayPrimeRx eliminates that choice, giving patients one product that immediately blurs the skin, treats with prescription actives over time, and holds makeup in place for up to 12 hours — maximising results and minimising effort.”

If you’ve ever battled pilling, flaking, or patchiness when layering skincare under foundation, you’ll understand why this launch matters. Until now, prescription acne and rosacea treatments have been purely functional — effective on breakouts but far from makeup-friendly. DayPrimeRx promises to change that by merging clinical care with cosmetic performance.

The hybrid formula pairs three dermatologist-prescribed actives, tailored to your specific skin concerns, with a primer base that smooths, blurs, and grips makeup all day. The result: instant glow, long-term clarity, and a finish that holds up whether you wear makeup or go bare.

“Research shows that consistency is key when it comes to clearing and preventing acne,” added Dr. Tolpinrud. “In a 12-week Curology clinical trial, over 90% of patients reported improvement in their acne as early as three weeks, and 95% saw clearer skin by week twelve. With Curology’s personalized formulas and ongoing care from licensed dermatology providers, we can continuously adjust treatment to match each patient’s evolving skin — that’s what makes lasting results possible.”

DayPrimeRx is available by subscription exclusively in the US at curology.com. After a short online consultation, including a few selfies and your skin goals, a licensed provider prescribes your custom formula. Your first month is free (just cover $5.45 for shipping), then $59.90 for a 60-day supply, including continued dermatology support.